The chicken embryo, as a classical developmental model, has been commonly used as a model for developmental, virological, and parasitological studies, as well as for in vivo studies of a number of neoplastic and non-neoplastic diseases. Chicken embryos can form abundant urothelial vessels during development, which provides favorable conditions for studying vascular development and neovascularization. Therefore, the chick embryo chorioallantoic membrane assay (CAM) can be widely used for screening and evaluating drugs on neovascularization.

Around the CAM assay, it can be applied to the in vivo study of cardiovascular disease drugs, anti-angiogenic tumor drugs, as well as the vascular irritation of the conjunctiva, genitalia, lips, nasal cavity, anus, skin and other related subjects. In recent years, with the in-depth study of gene function, CAM experiments can also be widely used for in vivo study of gene function in combination with gene carriers.

In addition, there are many reports confirming that a variety of cancer cells can be used to establish tumor xenograft models to evaluate tumor growth and metastasis by CAM. Chicken embryos are natural immunodeficient hosts because they are incubated for 15 days after fertilization to reach the normal physiological level of the immune system. In summary, CAM has the advantages of simple operation, shorter cycle time and easy observation of the results compared with other in vivo models. For more information, please contact: 13524733472

Do you need to add some featured in vivo experimental color charts in your research? Why don't you call up some recent studies to see the application scenarios of CAM experiments?

1、CAM experiment and gene function

2、 2.CAM experiments and drug development